bone disorders Tag

The most prominent form of synovial joint disease, osteoarthritis (OA), is characterized by joint degeneration, pain, and in some patients, articular neuropathy.  Chronic pain associated with OA is a major concern for which there are few viable treatments. The first line therapy used to treat OA pain is non-steroidal anti-inflammatory drugs (NSAIDs); however, withlong-term use their efficacy declines and they can lead to major adverse gastrointestinal and cardiovascular events.  Historically, OA has been classified as a non-inflammatory arthritis; however, there is now overwhelming evidence that synovitis can occur in response to pro inflammatory mediators being released into the joint. It is believed that this low-level inflammation contributes to degenerative changes that affect the entire joint leading to the development of peripheral sensitization and nociceptive pain . In addition to structural defects, there is growing evidence to suggest that approximately 30% of OA patients suffer from neuropathic pain. Thus, a therapeutic which can block inflammation, neuropathy, and pain is sorely needed The endocannabinoid system (ECS) plays an important physiological role in the regulation of tissue inflammation and pain. A functional ECS has been demonstrated in the joints of animals and humans, which acts tonically to maintain joint homeostasis.